In this paper we present a complex clinical case of a reconstruction of an oncologic defect in the mandibular area, including the different therapeutic steps, pathological diagnosis and several imaging tests. Dental rehabilitation was provided by means of a removable implant-supported prosthesis on a osteo-fascio-cutaneous fibula free graft. The patient received previously radiotherapy. The results are analyzed and discussed. The decision-making process was based on current related literature.