Influence on early osseointegration of dental implants installed with two different drilling protocols: a histomorphometric study in rabbit

Clinical Oral Implant Research. 22, 2011; 92-99


To evaluate early osseointegration of dental implants installed with two different drilling protocols.


Thirty-six cylindrical shape Mozo Grau implants, with a diameter of 3.75 and 11mm long, were placed into the distal condyle (submerged) of each femur of 18 New Zealand rabbits. In the control group, a 3.3mm diameter drill was used as the last one prior implant installation (stan- dard protocol). In the test group, the same procedure was carried out but an additional 3.5mm drill was used as the final one (oversized protocol) Thus, we could obtain different primary sta- bility at day 0 between groups. Sacrifice of the animals was after 2, 4 and 8 weeks.


The ISQ values were statistically significant different between groups at day 0 (control: 69.65; test: 64.81); and after 2 weeks (control: 77.93; test: 74). However, after 4 and 8 weeks the results were similar. BIC% showed a similar tendency, with 58.69% for the control group and 40.94% for the test group after 2 weeks, this difference being statistically significant. At 4- and 8-week interval, BIC% was similar.


At 2-week interval (early healing), osseointegration had been influenced by different primary stability at implant installation, being slower in the oversized protocol (lower primary stabili- ty), which could be especially risky in challenging clinical situations, such as soft bone (class 3 and 4) and early/ immediate loading. However, from 4 week on, these differences disappeared. Nevertheless, we have to consider that a direct transfer of the results of this animal study (time bone repair mechanisms) into clinic has to be done with caution.

Follow us