Guided bone regeneration study

Gaceta Dental. 2014


Objective: The histological and histomorphometric evaluation of the use of MG-Reguarde® combined with MG-Osteodrive® applied to bone regeneration, compared to a negative control.

Materials and method: Ten patients were included, aged 18 to 30 years, of both sexes, requiring the removal of a lower third molar. The wisdom tooth needed to be found with bone retention without breaking the mucosa. There were two random study groups: Group 1.- Regeneration with MG-Reguarde® and with MG-Osteodrive® (5 patients); Group 2.- No regeneration (5 patients). A bone sample was taken three and six months after surgery. The following variables were evaluated: new tissue area (units; μm2 x 104) and newly formed bone percentage (% units). A non-parametric U-Mann Whitney analysis was used.

Results: The experimental group showed better results in both variables than the control group, both in relation to the area of formed bone variable (7.06 x 104 μm2 ± 1.78 vs. 14.24 x 104 μm2 ± 2.69 at three months and 16.09 x 104 μm2 ± 4.19 vs. 23.18 x 104 μm2 ± 5.05 at six months; p<0.001) and the percentage of newly formed bone variable (6.32% ± 1.70 vs. 24.82% ± 4.56 at three months and 18.20% ± 5.15 vs. 61.71% ± 11.8 at six months; p<0.001).

Conclusions: From a clinical and statistical view, MG-Osteodrive membranes and MG-Reguarde bone substitute fulfil all the characteristics to be used in Oral Surgery, improving the percentages of bone regeneration in post-extraction alveolus after 3 and 6 months period when compared with control group.

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