{"id":4462,"date":"2021-06-30T10:49:40","date_gmt":"2021-06-30T08:49:40","guid":{"rendered":"https:\/\/www.ticareimplants.com\/?post_type=estudios-medicos&#038;p=4462"},"modified":"2021-06-30T10:49:40","modified_gmt":"2021-06-30T08:49:40","slug":"microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog","status":"publish","type":"estudios-medicos","link":"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/","title":{"rendered":"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog"},"content":{"rendered":"<p><strong>OBJECTIVE<\/strong><\/p>\n<p>To evaluate microbial and host-derived biomarker changes during experimental peri-implantitis in the Beagle dog. Limited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri-implantitis.<\/p>\n<p><strong>MATERIAL AND METHODS<\/strong><\/p>\n<p>In total, 36 implants (n dogs = 6) were assessed over 3 episodes of ligatureinduced peri-implantitis followed by a period of spontaneous progression. Implants with hybrid (H) and completely rough (R) surface designs were used. Clinical and radiographic parameters were recorded at 4 timepoints. Peri-implant sulcus fluid was collected from the buccal and lingual aspects of the implants. The presence of 7 bacterial species and 2 host-derived biomarkers was assessed during the study period.<\/p>\n<p><strong>RESULTS<\/strong><\/p>\n<p>Total bacterial counts were significantly correlated with marginal bone loss (MBL) (r =.21; P =.009). Further, <em>Phorphyromonas gulae<\/em> (<em>Pg<\/em>) and <em>Tannerella forsythia<\/em> (<em>Tf<\/em>) were commonly correlated with MBL, suppuration (SUP) and the sulcular bleeding index scores (mSBI) (P &lt;.05). Other bacteria were further correlated with SUP, mSBI, and MBL. While the analyzed bacteria dropped, <em>Prevotella intermedia<\/em> (<em>Pi<\/em>) further increased during the spontaneous progressive phase (P &lt;.05). Total bacterial load did not differ significantly between H and R implants. Host-derived IL-10 was undetected along the study period. IL-1\u03b2 positively correlated with probing pocket depth (r =.18; P =.03). During spontaneous progression, H implants displayed statistically significant lower levels of IL-1\u03b2 (P =.003).<\/p>\n<p><strong>CONCLUSION<\/strong><\/p>\n<p>Experimental peri-implantitis is associated with an increase in bacterial counts. While <em>Pg<\/em> and <em>Tf <\/em>are associated with ligature-induced disease progression, Pi augmented its load during the spontaneous progressive phase. IL-1\u03b2 is associated with pocket probing depth and influenced by implant surface characteristics during the spontaneous progression phase.<\/p>\n","protected":false},"parent":0,"template":"","medio-publicacion":[],"tematica-publicacion":[],"class_list":["post-4462","estudios-medicos","type-estudios-medicos","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog\" \/>\n<meta property=\"og:description\" content=\"OBJECTIVE To evaluate microbial and host-derived biomarker changes during experimental peri-implantitis in the Beagle dog. Limited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri-implantitis. MATERIAL AND METHODS In total, 36 implants (n dogs = 6) were assessed over 3 episodes of ligatureinduced peri-implantitis followed by a period of spontaneous progression. Implants with hybrid (H) and completely rough (R) surface designs were used. Clinical and radiographic parameters were recorded at 4 timepoints. Peri-implant sulcus fluid was collected from the buccal and lingual aspects of the implants. The presence of 7 bacterial species and 2 host-derived biomarkers was assessed during the study period. RESULTS Total bacterial counts were significantly correlated with marginal bone loss (MBL) (r =.21; P =.009). Further, Phorphyromonas gulae (Pg) and Tannerella forsythia (Tf) were commonly correlated with MBL, Read the whole content\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/\" \/>\n<meta property=\"og:site_name\" content=\"Ticare\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ticareimplants\/\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ticareimplants\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/\",\"url\":\"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/\",\"name\":\"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog\",\"isPartOf\":{\"@id\":\"https:\/\/www.ticareimplants.com\/#website\"},\"datePublished\":\"2021-06-30T08:49:40+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.ticareimplants.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Estudios m\u00e9dicos\",\"item\":\"https:\/\/www.ticareimplants.com\/estudios-medicos\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.ticareimplants.com\/#website\",\"url\":\"https:\/\/www.ticareimplants.com\/\",\"name\":\"Ticare\",\"description\":\"Tissue Care Philosophy\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.ticareimplants.com\/search\/{search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/","og_locale":"en_US","og_type":"article","og_title":"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog","og_description":"OBJECTIVE To evaluate microbial and host-derived biomarker changes during experimental peri-implantitis in the Beagle dog. Limited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri-implantitis. MATERIAL AND METHODS In total, 36 implants (n dogs = 6) were assessed over 3 episodes of ligatureinduced peri-implantitis followed by a period of spontaneous progression. Implants with hybrid (H) and completely rough (R) surface designs were used. Clinical and radiographic parameters were recorded at 4 timepoints. Peri-implant sulcus fluid was collected from the buccal and lingual aspects of the implants. The presence of 7 bacterial species and 2 host-derived biomarkers was assessed during the study period. RESULTS Total bacterial counts were significantly correlated with marginal bone loss (MBL) (r =.21; P =.009). Further, Phorphyromonas gulae (Pg) and Tannerella forsythia (Tf) were commonly correlated with MBL, Read the whole content","og_url":"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/","og_site_name":"Ticare","article_publisher":"https:\/\/www.facebook.com\/ticareimplants\/","twitter_card":"summary_large_image","twitter_site":"@ticareimplants","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/","url":"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/","name":"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog","isPartOf":{"@id":"https:\/\/www.ticareimplants.com\/#website"},"datePublished":"2021-06-30T08:49:40+00:00","breadcrumb":{"@id":"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ticareimplants.com\/en\/medical-publications\/microbial-and-host-derived-biomarker-changes-during-ligature-induced-and-spontaneous-peri-implantitis-in-the-beagle-dog\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ticareimplants.com\/en\/"},{"@type":"ListItem","position":2,"name":"Estudios m\u00e9dicos","item":"https:\/\/www.ticareimplants.com\/estudios-medicos\/"},{"@type":"ListItem","position":3,"name":"Microbial and host-derived biomarker changes during ligature induced and spontaneous peri-implantitis in the beagle dog"}]},{"@type":"WebSite","@id":"https:\/\/www.ticareimplants.com\/#website","url":"https:\/\/www.ticareimplants.com\/","name":"Ticare","description":"Tissue Care Philosophy","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ticareimplants.com\/search\/{search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.ticareimplants.com\/en\/wp-json\/wp\/v2\/estudios-medicos\/4462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ticareimplants.com\/en\/wp-json\/wp\/v2\/estudios-medicos"}],"about":[{"href":"https:\/\/www.ticareimplants.com\/en\/wp-json\/wp\/v2\/types\/estudios-medicos"}],"wp:attachment":[{"href":"https:\/\/www.ticareimplants.com\/en\/wp-json\/wp\/v2\/media?parent=4462"}],"wp:term":[{"taxonomy":"medio-publicacion","embeddable":true,"href":"https:\/\/www.ticareimplants.com\/en\/wp-json\/wp\/v2\/medio-publicacion?post=4462"},{"taxonomy":"tematica-publicacion","embeddable":true,"href":"https:\/\/www.ticareimplants.com\/en\/wp-json\/wp\/v2\/tematica-publicacion?post=4462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}